Detailed characterization of human pancreatic islets is key to elucidate the pathophysiology of all forms of diabetes mellitus, including its most common form known as type 2 diabetes (T2D). However, access to pancreatic islets is limited and pancreatic tissue for islet retrieval can be either obtained from cadaveric or brain-dead organ donors or from patients undergoing pancreatectomy, henceforth defined as living donors. Moreover, different protocols for procurement of islets substantially impact their molecular profiles and function. These factors coupled with heterogeneity among individuals result in analytical challenges to separate genuine disease pathology or differences between human donors from experimental noise.
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