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GLP-1 medications, like Ozempic<\/a>, Wegovy<\/a>, and Mounjaro<\/a>, have various known side effects, including nausea, fatigue, constipation, and diarrhea. <\/p>\n<\/div>\n However, a recent study published in The researchers analyzed 410,198 Reddit posts that mentioned either semaglutide<\/a> or tirzepatide<\/a>. They found a total of 67,008 users who self-reported using these medications. Of those, 43.5% posted about at least one side effect. <\/p>\n<\/div>\n Reproductive issues, such as menstrual irregularities and temperature-related complaints, like chills and hot flashes, were the most notable unrecognized side effects of GLP-1s. <\/p>\n<\/div>\n Jeffrey Lee<\/a>, MD, a double board-certified plastic surgeon and founder of JL Plastic Surgery in Boston, MA, who was not involved in the study, spoke to Healthline about these \u201chidden\u201d side effects, why they may occur, and what people may misunderstand about GLP-1s from social media posts. <\/p>\n<\/div>\n This interview has been lightly edited and condensed for clarity and length.<\/em><\/p>\n<\/div>\n<\/div>\n Lee: <\/strong>The most common side effects I see in practice are gastrointestinal<\/a>, things like nausea, bloating, or constipation. <\/p>\n<\/div>\n These are typically temporary and often dose-dependent, meaning they can improve over time or with a dosage adjustment.<\/p>\n<\/div>\n Of the lesser-known side effects mentioned in the study, I have occasionally had patients report fatigue<\/a>, but it\u2019s not something I see frequently. <\/p>\n<\/div>\n I have not personally seen most of the other symptoms highlighted in the study in a consistent or clinically significant way.<\/p>\n<\/div>\n <\/div>\n Lee: <\/strong>GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain<\/a>, particularly the hypothalamus<\/a>, which regulates many core functions, including hormones, temperature, and appetite.<\/p>\n<\/div>\n Because of this, it\u2019s plausible that some patients could experience broader systemic effects, including hormonal or temperature-related symptoms. <\/p>\n<\/div>\n That said, these effects are not yet well established clinically, and more research is needed to determine whether they are directly caused by the medication or influenced by factors such as weight loss, metabolic changes, or individual physiology.<\/p>\n<\/div>\n<\/div>\n Clinically, we are seeing that some patients report a reduced sense of reward from certain behaviors.<\/p>\n<\/div>\n