{"id":26401,"date":"2023-11-21T22:53:00","date_gmt":"2023-11-21T22:53:00","guid":{"rendered":"https:\/\/pickbydoc.com\/231121175349-htm\/"},"modified":"2023-11-21T22:53:00","modified_gmt":"2023-11-21T22:53:00","slug":"231121175349-htm","status":"publish","type":"post","link":"https:\/\/pickbydoc.com\/?p=26401","title":{"rendered":"Novel molecular mechanisms in the early development of diabetes mellitus"},"content":{"rendered":"<p>Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of\u00a0Anxa10\u00a0expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated\u00a0Anxa10\u00a0expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin secretory capacity.<\/p>\n<hr>\n<p>\n<strong>Source:<\/strong><br \/>\n<a href=\"https:\/\/www.sciencedaily.com\/releases\/2023\/11\/231121175349.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\nwww.sciencedaily.com<br \/>\n<\/a>\n<\/p>\n<p style=\"font-size:13px;color:#666;\">\n<strong>Medical Disclaimer:<\/strong><br \/>\nThis content is shared for informational and educational purposes only.<br \/>\nIt does not constitute medical, legal, or policy advice.<br \/>\nHealthcare decisions should always be made in consultation with qualified professionals.\n<\/p>\n<p><br \/>\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers conducted a gene expression analysis at the single-cell level on pancreatic islets from prediabetic and diabetic mouse models. Analysis results revealed upregulation of\u00a0Anxa10\u00a0expression in pancreatic beta cells during the early phases of diabetes, attributed to elevated blood glucose levels. This elevated\u00a0Anxa10\u00a0expression was found to influence intracellular calcium homeostasis, leading to a reduction in insulin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":26402,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[171],"tags":[17226,1754,8281,17225,3199,17224],"class_list":["post-26401","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions","tag-development","tag-diabetes","tag-early","tag-mechanisms","tag-mellitus","tag-molecular"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts\/26401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=26401"}],"version-history":[{"count":0,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts\/26401\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/media\/26402"}],"wp:attachment":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=26401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=26401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=26401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}