{"id":24969,"date":"2025-06-21T03:18:00","date_gmt":"2025-06-21T03:18:00","guid":{"rendered":"https:\/\/pickbydoc.com\/250620231852-htm\/"},"modified":"2025-06-21T03:18:00","modified_gmt":"2025-06-21T03:18:00","slug":"250620231852-htm","status":"publish","type":"post","link":"https:\/\/pickbydoc.com\/?p=24969","title":{"rendered":"Iron overload: The hidden culprit behind early Alzheimer\u2019s in Down syndrome"},"content":{"rendered":"<p>USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer&#8217;s in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions.<\/p>\n<hr>\n<p>\n<strong>Source:<\/strong><br \/>\n<a href=\"https:\/\/www.sciencedaily.com\/releases\/2025\/06\/250620231852.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\nwww.sciencedaily.com<br \/>\n<\/a>\n<\/p>\n<p style=\"font-size:13px;color:#666;\">\n<strong>Medical Disclaimer:<\/strong><br \/>\nThis content is shared for informational and educational purposes only.<br \/>\nIt does not constitute medical, legal, or policy advice.<br \/>\nHealthcare decisions should always be made in consultation with qualified professionals.\n<\/p>\n<p><br \/>\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer&#8217;s in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":24970,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[171],"tags":[12464,15586,8281,11060,6126,15585,14927],"class_list":["post-24969","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-conditions","tag-alzheimers","tag-culprit","tag-early","tag-hidden","tag-iron","tag-overload","tag-syndrome"],"jetpack_publicize_connections":[],"_links":{"self":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts\/24969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24969"}],"version-history":[{"count":0,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/posts\/24969\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=\/wp\/v2\/media\/24970"}],"wp:attachment":[{"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pickbydoc.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}